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KMID : 0617320030120010128
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Journal of Pharmacetical Sceiences Ewha Womans University
2003 Volume.12 No. 1 p.128 ~ p.130
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A Potential Cytotoxic Principle of Zingiber cassumunar
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Han, Ah-Reum
Lee, Eun-Jin/Min, Hye-Young/Kim, Hyang-Rim/Lee, Sang Kook/Seo, Eun-Kyoung
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Abstract
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A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3´,4´-dimethoxyphenyl)but-3-en-l-ol (2) and (E)-4-(3´,4´-dimethoxyphenyl)but-3-en-l-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC_(50) 18.80㎍/㎖).
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